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Sexual health communication between Asian-American adolescents and health-care providers

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Health care providers play an important role in providing accurate information to adolescents about sexual health issues, including prevention of pregnancy and sexually transmitted infections. There has been limited research, however, on how to best provide effective discussions about sexual health with Asian-American adolescents in a culturally sensitive manner.

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Female fertility is dependent on functional expression of the E3 ubiquitin ligase Itch

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Protein ubiquitination is known to result in its proteasomal degradation or to serve as a signal for tissue-specific cellular functions. Here it is reported that mice with a mutant form of the E3 ubiquitin ligase ITCH display reduced litter sizes due to a maternal effect. Mutant females had decreased numbers of implantations, corpa lutea, and […]

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Cell biology: Nuclear export of opioid growth factor receptor is CRM1 dependent

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The opioid growth factor receptor (OGFr) interacts with a specific opioid growth factor ligand (OGF), chemically termed [Met5]-enkephalin, to maintain homeostasis in a wide variety of normal and abnormal cells and tissues. The mechanism underlying the function of OGFr requires that the receptor translocates to the nucleus. However, the mechanism of nuclear export of OGFr […]

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Diabetic management: Subcutaneous insulin therapy fails to protect against oxidative stress and inflammation

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Today, the gold standard for insulin therapy is the subcutaneous injection of insulin (CSII), despite a non-physiological route of administration with suboptimal glycemic control showed in some patients. Inability of CSII therapy to prevent inflammation and oxidative stress was firstly demonstrated in vivo on treated-diabetic rats, presenting a high variability of glycogen storage associated with […]

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A human liver microphysiology platform for studying physiology, drug safety, and disease

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Currently available animal and human liver models provide limited predictions of human drug efficacy and toxicity, primarily due to metabolic differences and the limited ability of simple 2-D models to recapitulate the complex cellular interactions that lead to toxicity. To fill this gap we have developed a novel 4 cell type, 3-D, microfluidic, human liver […]

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A new way to discover DNA modifications

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DNA is made from four nucleosides, each known by its own letter — A, G, C, and T. However, since the structure of DNA was deciphered in 1953, scientists have discovered several other variants that are often added to the DNA sequences to replace one of the usual four letters.