Protein ubiquitination is known to result in its proteasomal degradation or to serve as a signal for tissue-specific cellular functions. Here it is reported that mice with a mutant form of the E3 ubiquitin ligase ITCH display reduced litter sizes due to a maternal effect. Mutant females had decreased numbers of implantations, corpa lutea, and extended estrous cycles. The results indicate for the first time that loss of functional ITCH disrupts female reproduction.
This full article appears on <a href="https://www.sciencedaily.com/releases/2016/02/160229182656.htm">Science Daily</a>