Machine-guided engineering of AAV capsids

Posted · Add Comment
scidaily-logo-rss

Taking a more systematic approach to the capsid protein-engineering problem, researchers mutated one by one each of the 735 amino acids within the AAV2 capsid, the best-known member of the AAV family, including all possible codon substitutions, insertions and deletions at each position. They generated a virus library containing about 200,000 variants and identified capsid changes that both maintained AAV2’s viability and improved its ‘homing’ potential (tropism) to specific organs in mice.

This full article appears on <a href="https://www.sciencedaily.com/releases/2019/11/191128172334.htm">Science Daily</a>

Leave a Reply

Your email address will not be published. Required fields are marked *